Blar i NTNU Open på forfatter "Beatson, Richard"
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Elucidating binding capacities of different sialic acid-carrying polymer substrates with Siglec-9 by Optical Tweezers - Studies of the importance of mucin glycosylation for cancer progression
Monshaugen, Ida (Master thesis, 2018)The experimental data regarding interaction studies and energy landscape presented in this master thesis were obtained using a dual-beam Optical Tweezers. The main objective of this study was to investigate the binding of ... -
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers
Hadjialirezaei, Soosan; Picco, Gianfranco; Beatson, Richard; Burchell, Joy; Stokke, Bjørn Torger; Sletmoen, Marit (Journal article; Peer reviewed, 2017)Carbohydrate–protein interactions govern many crucial processes in biological systems including cell recognition events. We have used the sensitive force probe optical tweezers to quantify the interactions occurring between ... -
The breast cancer-associated glycoforms of MUC1, MUC1-Tn and sialyl-Tn, are expressed in COSMC wild-type cells and bind the C-type lectin MGL
Beatson, Richard; Maurstad, Gjertrud; Picco, Gianfranco; Arulappu, Appitha; Coleman, Julia; Wandell, Hans H; Clausen, Henrik; Mandel, Ulla; Taylor-Papadimitriou, Joyce; Sletmoen, Marit; Burchell, Joy (Journal article, 2015)Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific ...